KMID : 0385520090220050432
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Analytical Science & Technology 2009 Volume.22 No. 5 p.432 ~ p.438
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Square wave voltammetric behaviors and determinations of ranitidine¤ýHCl in the pharmaceutical tablets
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Shin Soon-Ho
Hahn Young-Hee
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Abstract
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In order to develop the analytical method for the pharmaceutical tablets containing ranitidine¤ýHCl by square wave voltammetry (SWV), 5.00¡¿10?? M ranitidine¤ýHCl solutions prepared with phosphate buffers of various pH values were investigated by SWV. The well defined main peak due to the electrochemical reduction of -NO2 in the structure of ranitidine moved towards the cathodic direction by -70 §Æ/pH as the pH values were increased indicating the involvement of hydrogen in its reduction. The calibration curve, the plot of peak currents (Ip) vs. concentrations of ranitidine¤ýHCl in the range between 1.00¡¿10?? M and 1.00¡¿10?? M showed linearity with slopes of 232,530 §Ë/M (pH 6.14), 289,015 §Ë/M (pH 7.07) and 232,843 §Ë/M (pH 8.01). When one pharmaceutical tablet was simply dissolved in the phosphate buffer with a pH value of 6.14 and determined by standard addition method using SWV, the within-day precision study (n=4) resulted in the contents of ranitidine¤ýHCl as 171¡¾2.1 §· (102¡¾1.3% of the specified contents, RSD of 1.2%) in a tablet of Curan¢ç. The inter-day precision for 5 days was 1.1% of RSD. For Zantac¢ç the within-day precision study (n=4) showed the contents of ranitidine¤ýHCl as 167¡¾0.8 §· (99¡¾0.5% of the specified contents, RSD of 0.5%) in a tablet and the inter-day precision for 5 days was 0.3% of RSD.
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KEYWORD
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ranitidineHCl, square wave voltammetry, electrochemical reduction of -NO©ü
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